HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Reactant | 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carboxylic acid | HCID 71117807 | — |
| Reactant | 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde | HCID 86677550 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carbaldehyde | HCID 71117680 | — |
Reaction Steps
1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carbaldehyde (33) was prepared in a similar manner as that described for the synthesis of compound 20 using 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde (32) (150 mg, 0.41 mmol), Oxone (629 mg, 1.02 mmol), acetone (4 mL) and 0.2M sodium bicarbonate (4 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-7b2c658737154bcb88ff4b54009a12a0 |
| Source note | uspto-grants-2014_04 |