4-Fluoroaniline → HCID 178441226, compound

Participants

Reaction Steps

N-(4-fluorophenyl)-2,2-dimethyl-3-(2,3,6-trifluorophenyl)propanimidamide (35) was prepared in a similar manner as that described for the synthesis of compound 25 using 2,2-dimethyl-3-(2,3,6-trifluorophenyl)propanenitrile (34) (500 mg, 2.35 mmol), 4-fluoroaniline (0.38 mL, 4.0 mmol), trimethyl aluminum (2M in heptanes, 1.99 mL, 3.99 mmol) and toluene (10 mL).

Provenance & Evidence