4-Fluoroaniline → HCID 178441226, compound

HRID 2368495Notes

Reaction equation

HRID 2368495 reaction equation
FC1C(F)=CC=C(F)C=1C(=N)NC1C=CC(F)=CC=1.[CH3:20][C:21]([CH3:34])([CH2:24][C:25]1[C:30]([F:31])=[CH:29][CH:28]=[C:27]([F:32])[C:26]=1[F:33])[C:22]#[N:23].[F:35][C:36]1[CH:42]=[CH:41][C:39]([NH2:40])=[CH:38][CH:37]=1.C[Al](C)C>C1(C)C=CC=CC=1>[F:35][C:36]1[CH:42]=[CH:41][C:39]([NH:40][C:22](=[NH:23])[C:21]([CH3:20])([CH3:34])[CH2:24][C:25]2[C:30]([F:31])=[CH:29][CH:28]=[C:27]([F:32])[C:26]=2[F:33])=[CH:38][CH:37]=1

Participants

6

Reactant 4

HCID 97314-FluoroanilineHCID 16682925TrimethylaluminumHCID 71117360HCID 71117360, compoundHCID 178512046HCID 178512046, compound

Product 1

HCID 178441226HCID 178441226, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

N-(4-fluorophenyl)-2,2-dimethyl-3-(2,3,6-trifluorophenyl)propanimidamide (35) was prepared in a similar manner as that described for the synthesis of compound 25 using 2,2-dimethyl-3-(2,3,6-trifluorophenyl)propanenitrile (34) (500 mg, 2.35 mmol), 4-fluoroaniline (0.38 mL, 4.0 mmol), trimethyl aluminum (2M in heptanes, 1.99 mL, 3.99 mmol) and toluene (10 mL).

Sources & evidence

ORD record
ord-7fdc82ebc13c489a81ac817915afa410
Source dataset
uspto-grants-2014_04
Patent number
US08703776B2

Reaction notes

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