HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl 2-((2-chloro-6-fluorophenethyl)thio)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-fluorophenyl)-2-(tritylthio)-1H-imidazole-5-carboxylic acid | HCID 71117468 | — |
| Reactant | 1-(4-Fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide | HCID 86677541 | — |
| Reactant | 2-Chloro-6-fluorophenethyl methanesulfonate | HCID 86677554 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-((2-chloro-6-fluorophenethyl)thio)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate | HCID 71117392 | — |
Reaction Steps
Ethyl 2-((2-chloro-6-fluorophenethyl)thio)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (53) was prepared in a similar manner as that described for the synthesis of compound 9 using ethyl 1-(4-fluorophenyl)-2-mercapto-1H-imidazole-5-carboxylate (6) (700 mg, 2.62 mmol), 2-chloro-6-fluorophenethyl methanesulfonate (813 mg, 3.144 mmol), potassium carbonate (1.1 g, 7.86 mmol) in DMF (20 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-3b90d7188b654edfae7f26d0770fcc8e |
| Source note | uspto-grants-2014_04 |