反应详情

Ethyl 2-((2-chloro-6-fluorophenethyl)thio)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (53) was prepared in a similar manner as that described for the synthesis of compound 9 using ethyl 1-(4-fluorophenyl)-2-mercapto-1H-imidazole-5-carboxylate (6) (700 mg, 2.62 mmol), 2-chloro-6-fluorophenethyl methanesulfonate (813 mg, 3.144 mmol), potassium carbonate (1.1 g, 7.86 mmol) in DMF (20 mL).