HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Ethyl 2-((2-chloro-6-fluorophenethyl)sulfonyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | Ethyl 2-((2-chloro-6-fluorophenethyl)thio)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate | HCID 71117392 | — |
| Reactant | 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carboxylic acid | HCID 71117807 | — |
| Product | Ethyl 2-((2-chloro-6-fluorophenethyl)sulfonyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate | HCID 71117431 | — |
Reaction Steps
Ethyl 2-((2-chloro-6-fluorophenethyl)sulfonyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (54) was prepared in a similar manner as that described for the synthesis of compound 20 using ethyl 2-((2-chloro-6-fluorophenethyl)thio)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (53) (100 mg, 0.236 mmol), m-CPBA (122 mg, 0.708 mmol) in CH2Cl2 (10 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-6c956282e0494e0bbba78433fe5982b0 |
| Source note | uspto-grants-2014_04 |