HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 1-(4-Fluorophenyl)-2-(methyl(2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylic acid | HCID 71117327 | — |
| Reactant | methyl(2,3,6-trifluorobenzylamino)-1H-imidazole-5-carboxylate | HCID 86677557 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Fluorophenyl)-2-(methyl(2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylic acid | HCID 71117326 | — |
Reaction Steps
1-(4-Fluorophenyl)-2-(methyl(2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylic acid (71) was prepared in a similar manner as that described for the synthesis of compound 11 using 1-(4-fluorophenyl)-2-(methyl(2,3,6-trifluorobenzylamino)-1H-imidazole-5-carboxylate (70) (24 mg, 0.061 mmol) and 1N LiOH (5 mL) in THF (5 mL) and MeOH (5 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-ce148f6ac5894a2ca56b3b65c9e99004 |
| Source note | uspto-grants-2014_04 |