反应详情

1-(4-Fluorophenyl)-2-(methyl(2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylic acid (71) was prepared in a similar manner as that described for the synthesis of compound 11 using 1-(4-fluorophenyl)-2-(methyl(2,3,6-trifluorobenzylamino)-1H-imidazole-5-carboxylate (70) (24 mg, 0.061 mmol) and 1N LiOH (5 mL) in THF (5 mL) and MeOH (5 mL).