Hydrochloric Acid → Nilotinib Hydrochloride Anhydrous

Participants

Reaction Steps

Nilotinib (2 gm) was added to a mixture of water (20 ml) and concentrated hydrochloric acid (0.42 ml) at room temperature to obtain a clear solution. The solution was subjected to freeze drying at about −80 deg C. for 8 hours to obtain 2 gm of nilotinib hydrochloride crystalline form H1.

Provenance & Evidence