Hydrochloric Acid → Nilotinib Hydrochloride Anhydrous

HRID 2368542Notes

Reaction equation

HRID 2368542 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:21]([NH:23][C:24]2[CH:25]=[C:26]([C:36]([F:39])([F:38])[F:37])[CH:27]=[C:28]([N:30]3[CH:34]=[N:33][C:32]([CH3:35])=[CH:31]3)[CH:29]=2)=[O:22])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[ClH:40]>O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:21]([NH:23][C:24]2[CH:29]=[C:28]([N:30]3[CH:34]=[N:33][C:32]([CH3:35])=[CH:31]3)[CH:27]=[C:26]([C:36]([F:37])([F:39])[F:38])[CH:25]=2)=[O:22])=[CH:6][C:7]=1[NH:8][C:9]1[N:14]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[CH:12]=[CH:11][N:10]=1.[ClH:40]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 644241Nilotinib

Product 1

HCID 16006490Nilotinib Hydrochloride Anhydrous

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Nilotinib (2 gm) was added to a mixture of water (20 ml) and concentrated hydrochloric acid (0.42 ml) at room temperature to obtain a clear solution. The solution was subjected to freeze drying at about −80 deg C. for 8 hours to obtain 2 gm of nilotinib hydrochloride crystalline form H1.

Workup

  1. customto obtain a clear solution
  2. customto freeze drying at about −80 deg C

Sources & evidence

ORD record
ord-98236466ab2746c7a49a40c5d3953388
Source dataset
uspto-grants-2014_04
Patent number
US08703788B2

Reaction notes

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