HCID 66725524, compound → HCID 25062523, compound

HRID 2368579Notes

Reaction equation

COC1C=CC(C[N:8]2[C:16]3[C:15](=[O:17])[N:14]4[C:18]([CH3:21])=[N:19][N:20]=[C:13]4[N:12]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:11]=3[N:10]=[C:9]2N2C=NC=N2)=CC=1>FC(F)(F)C(O)=O>[CH3:21][C:18]1[N:14]2[C:15](=[O:17])[C:16]3[NH:8][C:9]([N:14]4[CH:13]=[N:20][N:19]=[CH:18]4)=[N:10][C:11]=3[N:12]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:13]2=[N:20][N:19]=1

Participants

Conditions

Temperature: 60 °C

Procedure

A mixture of 6-(4-methoxybenzyl)-3-methyl-9-pentyl-7-(1H-1,2,4-triazol-1-yl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one (53 mg, 0.12 mmol) in trifluoroacetic acid (10 mL) was stirred at 60° C. overnight. The mixture was concentrated and purified by preparative LC-MS to give the desired product (20 mg, 52%). LCMS calculated for C14H18N9O (M+H): 328.2. Found: 328.2.

Workup

concentrationThe mixture was concentrated
custompurified by preparative LC-MS

Sources & evidence

ORD record: ord-6ffe58b82060412dacc635d333d489af
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08703783B2

Reaction notes

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