Hydrochloric Acid → HCID 66725663, compound

HRID 2368608Notes

Reaction equation

HRID 2368608 reaction equation
C(OC(=O)[NH:10][CH2:11][C:12]1[N:16]2[C:17](=[O:29])[C:18]3[NH:19][CH:20]=[N:21][C:22]=3[N:23]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:15]2=[N:14][N:13]=1)C1C=CC=CC=1.[ClH:31]>CO.[Pd]>[ClH:31].[NH2:10][CH2:11][C:12]1[N:16]2[C:17](=[O:29])[C:18]3[NH:19][CH:20]=[N:21][C:22]=3[N:23]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:15]2=[N:14][N:13]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57600256benzyl[(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamate

Product 1

HCID 66725663HCID 66725663, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To the solution of benzyl[(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamate (0.30 g, 0.73 mmol) in methanol (20 mL) and 1 mL of conc. HCl was added 10% Pd/C under N2. The mixture was shaken under 30 PSI H2 for 3 hours. The reaction mixture was filtered through celite and concentrated to yield the desired product (210 mg, 92%). LCMS calculated for C12H18N7O (M+H): 276.2. Found: 276.2.

Workup

  1. filtrationThe reaction mixture was filtered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-af11578ac8ca4d3aaa0ed4cdcbd4ea89
Source dataset
uspto-grants-2014_04
Patent number
US08703783B2

Reaction notes

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