HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide → 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide | HCID 86664893 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide | HCID 86664892 | — |
Reaction Steps
Prepared analogously to example 154d by hydrogenation of the product obtained in (771f) using Raney nickel in THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703796B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-543ae5d2267346549c3773248a77fe4b |
| Source note | uspto-grants-2014_04 |