N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide → 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

HRID 2368663Notes

Reaction equation

HRID 2368663 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([N+:16]([O-])=O)[C:13]([NH:19][CH3:20])=[N:12][C:11]=2[O:21][CH2:22][CH:23]([F:25])[F:24])=[CH:4][CH:3]=1>[Ni].C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([NH2:16])[C:13]([NH:19][CH3:20])=[N:12][C:11]=2[O:21][CH2:22][CH:23]([F:24])[F:25])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 86664893N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide

Product 1

HCID 866648925-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 154d by hydrogenation of the product obtained in (771f) using Raney nickel in THF.

Workup

  1. customPrepared analogously to example 154d by hydrogenation of the product

Sources & evidence

ORD record
ord-543ae5d2267346549c3773248a77fe4b
Source dataset
uspto-grants-2014_04
Patent number
US08703796B2

Reaction notes

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