HCID 67357010, compound → HCID 67356339, compound

HRID 2368669Notes

Reaction equation

HRID 2368669 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[C:6]([NH2:15])[C:5](Br)=[C:4]([O:17][CH2:18][CH3:19])[N:3]=1>CO.CN(C=O)C.C1(P(C2C=CC=CC=2)[C-]2C=CC=C2)C=CC=CC=1.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2].CC(O)=O.CC(O)=O.[Pd]>[NH2:1][C:2]1[C:7]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[C:6]([NH2:15])[C:5]([C:8]([O:10][CH3:11])=[O:9])=[C:4]([O:17][CH2:18][CH3:19])[N:3]=1

Participants

6

Reactant 1

HCID 67357010HCID 67357010, compound

Product 1

HCID 67356339HCID 67356339, compound

Reagents, catalysts & solvents 4

HCID 635956Ferrocene-1,1'-bis-(diphenylphosphine)CatalystHCID 4144353Palladium (II) acetateCatalystHCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to example 377e by carbonylation of the product obtained in (842c) using 1,1′-bis-diphenylphosphino-ferrocene, palladium-II-acetate and TEA in methanol and DMF.

Workup

  1. customPrepared analogously to example 377e by carbonylation of the product

Sources & evidence

ORD record
ord-befb7ae4d5734d3f99b12bafcd7c2535
Source dataset
uspto-grants-2014_04
Patent number
US08703796B2

Reaction notes

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