(2E)-3-(Dimethylamino)-1-(4-Pyridinyl)-2-Propen-1-One → Imatinib Impurity 38

HRID 2368781Notes

Reaction equation

HRID 2368781 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=O.[N+]([O-])(O)=O.[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][C:20]=1[NH:28][C:29]([NH2:31])=[NH:30]>>[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][C:20]=1[NH:28][C:29]1[N:31]=[C:5]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[CH:4]=[CH:3][N:30]=1

Participants

3

Reactant 2

HCID 5396716(2E)-3-(Dimethylamino)-1-(4-Pyridinyl)-2-Propen-1-OneHCID 178426711HCID 178426711, compound

Product 1

HCID 58579018Imatinib Impurity 38

Procedure

The title compound was prepared by condensation reaction between (2E)-3-(dimethylamino)-1-pyridin-4-ylprop-2-en-1-one and N-(2-methyl-5-nitrophenyl)guanidine nitrate, according to the procedure described in Step C of EXAMPLE 8. MS (M+1)=308.11.

Sources & evidence

ORD record
ord-91220e99f455473f8c17c74ee0d33828
Source dataset
uspto-grants-2014_04
Patent number
US08703771B2

Reaction notes

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