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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368781Generated: November 1, 2026

(2E)-3-(Dimethylamino)-1-(4-Pyridinyl)-2-Propen-1-One → Imatinib Impurity 38

https://huagongshe.com/reaction/2368781

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2E)-3-(Dimethylamino)-1-(4-Pyridinyl)-2-Propen-1-OneHCID 5396716—
ReactantHCID 178426711HCID 178426711—
ProductImatinib Impurity 38HCID 58579018—

Reaction Steps

The title compound was prepared by condensation reaction between (2E)-3-(dimethylamino)-1-pyridin-4-ylprop-2-en-1-one and N-(2-methyl-5-nitrophenyl)guanidine nitrate, according to the procedure described in Step C of EXAMPLE 8. MS (M+1)=308.11.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08703771B2
Source datasetuspto-grants-2014_04
ORD IDord-91220e99f455473f8c17c74ee0d33828
Source noteuspto-grants-2014_04