HCID 23154377, compound → HCID 46831580, compound

HRID 2368782Notes

Reaction equation

HRID 2368782 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C@@H:8]2[C:16]3[C:11](=[CH:12][C:13]([C:17](OCC)=[O:18])=[CH:14][CH:15]=3)[CH2:10][CH2:9]2)[CH2:4][CH2:3]1.[CH3:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][C:24]=1[NH:30][C:31]1[N:36]=[C:35]([C:37]2[CH:42]=[CH:41][N:40]=[CH:39][CH:38]=2)[CH:34]=[CH:33][N:32]=1>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C@@H:8]2[C:16]3[C:11](=[CH:12][C:13]([C:17]([NH:29][C:26]4[CH:27]=[CH:28][C:23]([CH3:22])=[C:24]([NH:30][C:31]5[N:36]=[C:35]([C:37]6[CH:42]=[CH:41][N:40]=[CH:39][CH:38]=6)[CH:34]=[CH:33][N:32]=5)[CH:25]=4)=[O:18])=[CH:14][CH:15]=3)[CH2:10][CH2:9]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 23154377HCID 23154377, compoundHCID 67455735HCID 67455735, compound

Product 1

HCID 46831580HCID 46831580, compound

Procedure

The title compound was prepared by condensation reaction between ethyl (1S)-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxylate and 4-methyl-N(3)-(4-pyridin-4-ylpyrimidin-2-yl)benzene-1,3-diamine, according to the procedure described in Step C of EXAMPLE 11. MS (M+1)=520.27. 1HNMR (DMSO-d6, ppm): δ 10.14 (s, 1H); 9.04 (s, 1H); 8.07 (d, J=4.4 Hz, 2H); 8.55 (d, J=4.8 Hz, 1H); 8.06 (s, 1H); 8.04 (d, J=4.4 Hz, 2H); 7.78 (s, 1H); 7.75 (d, J=8.8 Hz, 1H); 7.45 (d, J=7.6 Hz, 1H); 7.44 (d, J=4.8 Hz, 1H); 7.35 (d, J=7.6 Hz, 1H); 7.18 (d, J=8.8 Hz, 1H); 4.31 (t, J=7.2 Hz, 1H); 2.0-3.0 (m, 10H); 2.19 (s, 3H); 2.12 (s, 3H); 2.04 (m, 2H).

Sources & evidence

ORD record
ord-f422d302cc3c44ecb41761b308fa6977
Source dataset
uspto-grants-2014_04
Patent number
US08703771B2

Reaction notes

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