Morpholine → HCID 59632481, compound

HRID 2369047Notes

Reaction equation

HRID 2369047 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][CH2:14]Cl)[N:11]=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)=[CH:4][CH:3]=1.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>C(#N)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][CH2:14][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:11]=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 59632103HCID 59632103, compound

Product 1

HCID 59632481HCID 59632481, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5-(4-bromophenyl)-1-(2-chloroethyl)-3-(trifluoromethyl)-1H-pyrazole (200 mg, 0.56 mmol) and morpholine (0.245 mL, 5 equiv) in acetonitrile (2 mL) was stirred overnight at 90° C. Evaporation of solvent gave of 4-(2-(5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethyl)morpholine. MS (ES): 404 [M+H]+.

Workup

  1. customEvaporation of solvent

Sources & evidence

ORD record
ord-751d16c7179c45e2b46810f87a39aed1
Source dataset
uspto-grants-2014_04
Patent number
US08703805B2

Reaction notes

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