p-Toluenesulfonic acid → HCID 66996901, compound

Participants

Reaction Steps

43.6 g (0.60 mol) of isobutyl aldehyde, 62.5 g (0.55 mol) of L-lactic acid, and 1.06 g (0.05 mmol) of p-toluene sulfonic acid were dissolved in 50 ml of n-pentane, and the mixture was refluxed for 8 hours in a 500-ml flask attached to a reflux condenser comprising a Dean-Stark fractionator. After the reaction, the reaction mixture was neutralized and washed with a sodium bicarbonate aqueous solution, followed by extraction with ether. Thereafter, the extract was dried with anhydrous magnesium sulfate. Thereafter, ether was distilled off, thereby giving 62.7 g (yield=79.2%) of 5-methyl-2-isopropyl-1,3-dioxolan-4-one as a diastereomer mixture.

Provenance & Evidence