反应详情

400 mg (0.82 mmol) of the compound from Example 4A are initially charged in 8 ml of dry DMF. After addition of 110 mg (0.99 mmol) of potassium tert-butoxide, the mixture is stirred at RT for RT. A solution of 74 mg (0.82 mmol) of methyl glycolate in 1 ml of dry DMF is then added dropwise, and the reaction mixture is stirred at RT for 20 h. The solvent is then removed on a rotary evaporator and the residue is directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

1. stirringthe reaction mixture is stirred at RT for 20 h
2. customThe solvent is then removed on a rotary evaporator
3. customthe residue is directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5)