反应详情

A solution of 70 mg (0.14 mmol) of the compound from Example 4A and 27 mg (0.30 mmol) of beta-alanine in 2 ml of DMF is stirred at RT for 8 h. The mixture is then stirred at +90° C. for 2 h. After cooling to RT the reaction mixture is purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

1. customis purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5)