1-Methyl-4-piperidone → HCID 46239912, compound

HRID 2369265Notes

Reaction equation

HRID 2369265 reaction equation
CN1[CH2:24][CH2:23][C:5]2[N:6]([CH2:14][CH2:15][C:16]3[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=3)[C:7]3[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][C:12]=3[C:4]=2[CH2:3]1.[O:25]1CCC(=O)CC1.CN1CCC(=O)CC1>>[CH3:13][C:10]1[CH:9]=[CH:8][C:7]2[N:6]([CH2:14][CH2:15][C:16]3[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=3)[C:5]3[CH2:23][CH2:24][O:25][CH2:3][C:4]=3[C:12]=2[CH:11]=1

Participants

4

Reactant 3

HCID 740491-Methyl-4-piperidoneHCID 121599Tetrahydro-4H-pyran-4-oneHCID 197033Latrepirdine

Product 1

HCID 46239912HCID 46239912, compound

Procedure

8-Methyl-5-[2-(6-methyl-pyridin-3-yl)-ethyl]-1,3,4,5-tetrahydro-pyrano[4,3-b]indole is prepared in an analagous manner to Dimebon, except that tetrahydro-pyran-4-one is used in the final step in place of 1-methyl-piperidin-4-one.

Sources & evidence

ORD record
ord-e823fc3524f549cfb5c59ea383229a8b
Source dataset
uspto-grants-2014_04
Patent number
US08703952B2

Reaction notes

Loading…