反应详情

温度

50 °C

Under a nitrogen atmosphere, 12.4 g (0.326 mol) of lithium aluminum hydride was added little by little to a solution of 35 g (0.13 mol) of methyl 4,8,12-trimethyltridec-3-enoate in dry tetrahydrofuran (320 mL) at 0° C. After being stirred at 50° C. for 2 hours, the reaction mixture was cooled on ice, followed by careful addition of saturated sodium sulfate aqueous solution until the resulting gray suspension turned white. Sodium sulfate was added to the solution at room temperature for drying. After filtration, the filtrate was concentrated to obtain 31 g of the title compound (99% yield) as a colorless transparent liquid. The results of NMR analysis of the obtained compound are as shown below.

1. temperaturethe reaction mixture was cooled on ice
2. customfor drying
3. filtrationAfter filtration
4. concentrationthe filtrate was concentrated