Hydrochloric Acid → HCID 20304517, compound

HRID 236974Notes

Reaction equation

HRID 236974 reaction equation
[BH4-].[Na+].[O:3]=[C:4]1[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[O:7][C:6]2[C:13]([CH2:21][C:22](=[O:24])[CH3:23])=[C:14]3[C:19](=[CH:20][C:5]1=2)[CH2:18][CH2:17][CH2:16][CH2:15]3.Cl>[OH-].[Na+]>[OH:24][CH:22]([CH3:23])[CH2:21][C:13]1[C:6]2[O:7][C:8]([C:10]([OH:12])=[O:11])=[CH:9][C:4](=[O:3])[C:5]=2[CH:20]=[C:19]2[C:14]=1[CH2:15][CH2:16][CH2:17][CH2:18]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 20304583HCID 20304583, compound

Product 1

HCID 20304517HCID 20304517, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent2×

Procedure

To a stirred solution of sodium borohydride (0.4 g) in 0.02 N aqueous sodium hydroxide (30 ml) was added dropwise a solution of 4-oxo-10-(2-oxopropyl)-6,7,8,9-tetrahydro-4H-naphtho[2,3-b]pyran-2carboxylic acid (2.3 g) in 0.02N aqueous sodium hydroxide (100 ml). The resulting solution was stirred at ambient temperature for 20 hours, then cooled in ice and acidified with dilute hydrochloric acid. The precipitate was filtered washed with water and dried giving the title compound as a white solid, mp 235°.

Workup

  1. temperaturecooled in ice
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-dcac160a48ac4f5abf057420fc0ca7a1
Source dataset
uspto-grants-1979_06
Patent number
US04159273

Reaction notes

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