Succinic Acid → HCID 86605191, compound

HRID 2369770Notes

Reaction equation

HRID 2369770 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:9]([O-:18])(=[O:17])[C:10]1[C:11](=[CH:13][CH:14]=[CH:15][CH:16]=1)[OH:12].[Na+:19]>O>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:9]([O-:18])(=[O:17])[C:10]1[C:11](=[CH:13][CH:14]=[CH:15][CH:16]=1)[OH:12].[Na+:19]

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 16760658Sodium Salicylate

Product 1

HCID 86605191HCID 86605191, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

220 grams of microcrystalline cellulose (Avicel PH101, FMC, Philadelphia, USA), 200 grams of succinic acid (Sigma) and 20 grams of sodium salicylate (Fluka, Buchs, Switzerland) were added to the bowl of a Kenwood food mixer. The mixture was blended for 3 minutes at 60 rpm. Water was added gradually while mixing to granulate the blend. When the granulate was deemed to have reached a consistency suitable for extrusion (230 ml water added), addition was stopped and mixing continued for a further 10 minutes. The material was then extruded using a Caleva Model 10 extruder (Caleva, Sturminster Newton, Dorest, UK) at 15 rpm. The diameter of the holes on the extruder was 1 mm. The extrudate was then spheronised in approximately 45 gram batches using a Caleva Model 120 spheroniser (Caleva, Sturminster Newton, Dorest, UK) for 10 minutes at setting 75 (2250 rpm). The pellets were dried overnight in an oven at 50° C. The final yield of dried pellets was 359 grams.

Workup

  1. additionwhile mixing
  2. additionmixing
  3. waitcontinued for a further 10 minutes
  4. customfor 10 minutes
  5. customThe pellets were dried overnight in an oven at 50° C

Sources & evidence

ORD record
ord-d1059e808b964c429cf99ab14ef96052
Source dataset
uspto-grants-2014_04
Patent number
US08709996B2

Reaction notes

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