Succinic Acid → HCID 86605191, compound

Participants

Reaction Steps

220 grams of microcrystalline cellulose (Avicel PH101, FMC, Philadelphia, USA), 200 grams of succinic acid (Sigma) and 20 grams of sodium salicylate (Fluka, Buchs, Switzerland) were added to the bowl of a Kenwood food mixer. The mixture was blended for 3 minutes at 60 rpm. Water was added gradually while mixing to granulate the blend. When the granulate was deemed to have reached a consistency suitable for extrusion (230 ml water added), addition was stopped and mixing continued for a further 10 minutes. The material was then extruded using a Caleva Model 10 extruder (Caleva, Sturminster Newton, Dorest, UK) at 15 rpm. The diameter of the holes on the extruder was 1 mm. The extrudate was then spheronised in approximately 45 gram batches using a Caleva Model 120 spheroniser (Caleva, Sturminster Newton, Dorest, UK) for 10 minutes at setting 75 (2250 rpm). The pellets were dried overnight in an oven at 50° C. The final yield of dried pellets was 359 grams.

Provenance & Evidence