HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → (1S,3Z)-3-{2-[(1R,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Vitamin D3 | HCID 5280795 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | (1S,3Z)-3-{2-[(1R,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol | HCID 12303099 | 61.3% |
Reaction Steps
To a solution of Vitamin D3 (750 mgs) in hexane (20 ml) was added iodine (2 mgs). After stirring for 1 hr. at 20° the solution was washed with aqueous sodium thiosulphate, water and dried over sodium sulphate. After removal of the solvent, chromatography afforded trans-vitamin D3 (460mgs).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04159326 |
| Source dataset | uspto-grants-1979_06 |
| ORD ID | ord-663b0618c75145368eab0ce7fa61ecd4 |
| Source note | uspto-grants-1979_06 |