HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-[(3-methylphenyl)methyl]-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one → 4b,12-Difluoro-5-hydroxy-6b-(2-hydroxy-acetyl)-4a,6a-dimethyl-8-quinolin-2-ylmethyl-4b,5,6,6a,6b,7,8,9,9a,10,10a,10b,11,12-tetradecahydro-4aH-8-aza-pentaleno[2,1-a]phenanthren-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-[(3-methylphenyl)methyl]-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one | HCID 71245304 | — |
| Reactant | HCID 71245375 | HCID 71245375 | — |
| Product | 4b,12-Difluoro-5-hydroxy-6b-(2-hydroxy-acetyl)-4a,6a-dimethyl-8-quinolin-2-ylmethyl-4b,5,6,6a,6b,7,8,9,9a,10,10a,10b,11,12-tetradecahydro-4aH-8-aza-pentaleno[2,1-a]phenanthren-2-one | HCID 77993131 | — |
Reaction Steps
The title compound was prepared from compound 11 (130 mg, 0.215 mmol) following the procedure described in Example 5 for the synthesis of compound 9. Compound 12 (68 mg, 56% yield) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710037B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-7b81a0f1b56c4e07842d6c281772dfcf |
| Source note | uspto-grants-2014_04 |