Hydrochloric Acid → HCID 86672702, compound

HRID 2369893Notes

Reaction equation

HRID 2369893 reaction equation
C[O:2][CH:3](OC)[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:18][CH3:19])=[CH:11][C:12]=2[C:14]([O:16][CH3:17])=[O:15])[CH:7]=[N:6]1.Cl>O1CCOCC1>[CH3:19][O:18][C:10]1[CH:9]=[C:8]2[C:13](=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=1)[N:5]([CH2:4][CH:3]=[O:2])[N:6]=[CH:7]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66899438HCID 66899438, compound

Product 1

HCID 86672702HCID 86672702, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
75 °C

Procedure

To methyl 1-(2,2-dimethoxyethyl)-5-methoxy-1H-indazole-7-carboxylate (161 mg, 0.5 mmol) from Step G above in 1,4-dioxane (3 ml) was added 2N hydrogen chloride (3 ml) and the reaction mixture was heated to 75° C. for 2 h. The solvent was concentrated in vacuo to afford methyl 5-methoxy-1-(2-oxoethyl)-1H-indazole-7-carboxylate: MS (ESI+) m/z 249 (M+H).

Workup

  1. concentrationThe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-2a06b15fbbd145b7944e0a3f6b11a66a
Source dataset
uspto-grants-2014_04
Patent number
US08710046B2

Reaction notes

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