反应详情

温度

0 °C

2-chloro-1-(1-methyl-1H-pyrrol-2-yl)ethanol (Croce, P. D.; Ferraccioli, R.; Ritieni, A. Synthesis, 1990, 212-213) (2.05 g) is dissolved in methanol (40 mL) and added dropwise to a 2.0 M solution of methylamine in methanol (65 mL) at 0° C. The reaction mixture is stirred at 0° C. for 1 h and then allowed to warm to room temperature. The reaction mixture is stirred at room temperature for 18 h and then cooled to 0° C. Sodium borohydride (0.738 g) in H2O (40 mL) is added dropwise. The reaction mixture is stirred at 0° C. for 30 min and then allowed to warm to room temperature. The reaction mixture is stirred at room temperature for 18 h. An additional 0.738 g (19.5 mmol) of sodium borohydride is added and the reaction mixture is stirred at room temperature for 18 h. The reaction is quenched with a 1 N HCl solution and then concentrated in vacuo to remove methanol. The aqueous layer is adjusted to pH 12 with a 2 N NaOH solution and extracted with CH2Cl2 (4×100 mL). The combined organic layers are dried (MgSO4), filtered, and concentrated in vacuo. The resulting yellow oil is crystallized from ethyl acetate to yield 0.772 g of the title compound as a white solid.

1. customSynthesis, 1990, 212-213) (2.05 g)
2. temperatureto warm to room temperature
3. stirringThe reaction mixture is stirred at room temperature for 18 h
4. temperaturecooled to 0° C
5. stirringThe reaction mixture is stirred at 0° C. for 30 min
6. temperatureto warm to room temperature
7. stirringThe reaction mixture is stirred at room temperature for 18 h
8. stirringthe reaction mixture is stirred at room temperature for 18 h
9. customThe reaction is quenched with a 1 N HCl solution
10. concentrationconcentrated in vacuo
11. customto remove methanol
12. extractionextracted with CH2Cl2 (4×100 mL)
13. dry with materialThe combined organic layers are dried (MgSO4)
14. filtrationfiltered
15. concentrationconcentrated in vacuo
16. customThe resulting yellow oil is crystallized from ethyl acetate