反应详情

7-(Quinuclidin-4-ylmethyl)-8,9-dihydro-[1,4]diazepino[6,7,1-hi]indazol-6(7H)-one (267 mg, 0.9 mmol) from Step H above was dissolved in 1.25 M HCl in methanol and concentrated under reduced pressure to give 7-(quinuclidin-4-ylmethyl)-8,9-dihydro-[1,4]diazepino[6,7,1-hi]indazol-6(7H)-one hydrochloride as an off-white solid (299 mg, 100%): 1H NMR (500 MHz, D2O) δ 8.04 (s, 1H), 7.92 (d, J=7.0 Hz, 2H), 7.21 (t, J=8.0 Hz, 1H), 4.54 (s, 2H), 3.86 (s, 2H), 3.55 (s, 2H), 3.23 (t, J=7.5 Hz, 6H), 1.83 (t, J=7.5 Hz, 6H); MS (ESI+) m/z 311 (M+H).

1. concentrationconcentrated under reduced pressure