Bromine → HCID 20290839, compound

HRID 236995Notes

Reaction equation

HRID 236995 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[O:10])=[CH:4][CH:3]=1.[Br:16]Br>CCOCC.C(Cl)Cl>[Br:16][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[C:9]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)=[O:10]

Participants

5

Reactant 2

HCID 24408BromineHCID 12751641HCID 12751641, compound

Product 1

HCID 20290839HCID 20290839, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 70.0 g (0.32 mole) of 2-(4-fluorophenyl-1-(2-thienyl)ethanone in 600 ml of ether was added dropwise a solution of 56.0 g (0.35 mole) of bromine in 120 ml of methylene chloride at room temperature. The reaction mixture was concentrated under vacuum to give 123.0 g of 2-bromo-2-(4-fluorophenyl)-1-(2-thienyl)ethanone as an oil.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-40333d8475ee4c45a9b7aee47164a2ad
Source dataset
uspto-grants-1979_06
Patent number
US04159338

Reaction notes

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