Thiophene → HCID 21314983, compound

HRID 237002Notes

Reaction equation

HRID 237002 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[S:13]1[CH:17]=[CH:16][CH:15]=[CH:14]1.FC(F)(F)C(OC(=O)C(F)(F)F)=O>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([C:14]2[S:13][CH:17]=[CH:16][CH:15]=2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 8030ThiopheneHCID 9845Trifluoroacetic anhydrideHCID 798743,4-Dichlorophenylacetic acid

Product 1

HCID 21314983HCID 21314983, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the procedure described in Example 4A, 100.0 g of 3,4-dichlorophenylacetic acid, 242.0 g of thiophene and 144.0 g of trifluoroacetic anhydride gave from methanol 61.7 g of 2-(3,4-dichlorophenyl)-1-(2-thienyl)ethanone, m.p. 59.5-60.5.

Sources & evidence

ORD record
ord-38fa302fcfd44a8c8cbc96a1a922825d
Source dataset
uspto-grants-1979_06
Patent number
US04159338

Reaction notes

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