Ammonium thiocyanate → HCID 178527840, compound

HRID 237003Notes

Reaction equation

HRID 237003 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9](O)[C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[S-:18][C:19]#[N:20].[NH4+:21]>C(O)CC>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:20]=[C:19]([SH:18])[NH:21][C:10]=2[C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 15666Ammonium thiocyanateHCID 21314991HCID 21314991, compound

Product 1

HCID 178527840HCID 178527840, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

By the procedure described in the second paragraph of Example 2F, 45.0 g (0.16 mole) of 2-(3,4-dichlorophenyl)-2-hydroxy-1-(2-thienyl)ethanone was reacted with ammonium thiocyanate in 1-propanol at reflux to afford 32.6 g of 4-(3,4-dichlorophenyl)-5-(2-thienyl)-1H-2-imidazolethiol m.p. 263°-5°. (recrystallized from 1-butanol).

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-25e0667c51f74ce58d73c829434cd8b1
Source dataset
uspto-grants-1979_06
Patent number
US04159338

Reaction notes

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