反应详情

By the procedure described in the second paragraph of Example 2F, 45.0 g (0.16 mole) of 2-(3,4-dichlorophenyl)-2-hydroxy-1-(2-thienyl)ethanone was reacted with ammonium thiocyanate in 1-propanol at reflux to afford 32.6 g of 4-(3,4-dichlorophenyl)-5-(2-thienyl)-1H-2-imidazolethiol m.p. 263°-5°. (recrystallized from 1-butanol).

1. temperatureat reflux