Tetrafluoroethylene → HCID 178506050, compound

HRID 237009Notes

Reaction equation

HRID 237009 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([SH:18])[NH:10][C:11]=2[C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:19][C:20]([F:24])=[C:21]([F:23])[F:22]>>[C:1]1([C:7]2[N:8]=[C:9]([S:18][C:21]([F:23])([F:22])[CH:20]([F:24])[F:19])[NH:10][C:11]=2[C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 8301TetrafluoroethyleneHCID 178527827HCID 178527827, compound

Product 1

HCID 178506050HCID 178506050, compound

Procedure

4-Phenyl-5-(3-pyridyl)-1H-2-imidazolethiol (2.0 g; 7.9 mmoles) was reacted with 5.0 g (50 mmoles) of tetrafluoroethylene and the crude product purified by chromatography on Silicar CCNo. 7 with chloroform to afford 800 mg of 4-phenyl 5-(3-pyridyl)-2-(1,1,2,2-tetrafluoroethylthio)-1H-imidazole, m.p. 153°-154° (recrystallized from toluene).

Workup

  1. customthe crude product purified by chromatography on Silicar CCNo
  2. custom7 with chloroform to afford
  3. custom800 mg of 4-phenyl 5-(3-pyridyl)-2-(1,1,2,2-tetrafluoroethylthio)-1H-imidazole, m.p. 153°-154° (recrystallized from toluene)

Sources & evidence

ORD record
ord-8b2fab2b9f544b839f052518bb73d201
Source dataset
uspto-grants-1979_06
Patent number
US04159338

Reaction notes

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