反应详情

A solution of 3,4-dichloroaniline, cycloheptene oxide, and concentrated HCl (2 ml.) is heated at reflux temperature for seven (7) days. The unreacted epoxide is evaporated and the residue is treated with excess ethereal HCl, and a syrup results. This is washed with ether. The residue is crystallized and recrystallized from methanol/ether (1/5.5, v/v) to give trans-3,4-dichloro-N-(2-hydroxycycloheptyl)aniline, hydrochloride salt.

1. customThe unreacted epoxide is evaporated
2. additionthe residue is treated with excess ethereal HCl
3. customa syrup results
4. washThis is washed with ether
5. customThe residue is crystallized
6. customrecrystallized from methanol/ether (1/5.5