3,4-Difluorobenzeneboronic acid → 3-(3,4-difluorophenyl)dihydro-2H-pyran-4(3H)-one

HRID 2370190Notes

Reaction equation

HRID 2370190 reaction equation
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][C:7]=1[F:8].I[CH:13]1[C:18](OC)([O:19]C)[CH2:17][CH2:16][O:15][CH2:14]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:13]2[C:18](=[O:19])[CH2:17][CH2:16][O:15][CH2:14]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 27343373,4-Difluorobenzeneboronic acidHCID 580753843-iodo-4,4-dimethoxytetrahydro-2H-pyran

Product 1

HCID 580755413-(3,4-difluorophenyl)dihydro-2H-pyran-4(3H)-one

Procedure

3,4-difluorophenylboronic acid was reacted as described in Intermediate X(2) with 3-iodo-4,4-dimethoxytetrahydro-2H-pyran (Intermediate X(1)) to give 3-(3,4-difluorophenyl)dihydro-2H-pyran-4(3H)-one (Intermediate Y(2)).

Sources & evidence

ORD record
ord-d38c12971c5843b797072432eb6926b9
Source dataset
uspto-grants-2014_04
Patent number
US08710061B2

Reaction notes

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