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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2370190Generated: October 30, 2026

3,4-Difluorobenzeneboronic acid → 3-(3,4-difluorophenyl)dihydro-2H-pyran-4(3H)-one

https://huagongshe.com/reaction/2370190

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Difluorobenzeneboronic acidHCID 2734337—
Reactant3-iodo-4,4-dimethoxytetrahydro-2H-pyranHCID 58075384—
Product3-(3,4-difluorophenyl)dihydro-2H-pyran-4(3H)-oneHCID 58075541—

Reaction Steps

3,4-difluorophenylboronic acid was reacted as described in Intermediate X(2) with 3-iodo-4,4-dimethoxytetrahydro-2H-pyran (Intermediate X(1)) to give 3-(3,4-difluorophenyl)dihydro-2H-pyran-4(3H)-one (Intermediate Y(2)).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08710061B2
Source datasetuspto-grants-2014_04
ORD IDord-d38c12971c5843b797072432eb6926b9
Source noteuspto-grants-2014_04