4-(Trifluoromethyl)phenylboronic acid → 3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-one

HRID 2370195Notes

Reaction equation

HRID 2370195 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.I[CH:15]1[C:20](OC)([O:21]C)[CH2:19][CH2:18][O:17][CH2:16]1>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([CH:15]2[C:20](=[O:21])[CH2:19][CH2:18][O:17][CH2:16]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 580753843-iodo-4,4-dimethoxytetrahydro-2H-pyran

Product 1

HCID 580753073-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-one

Procedure

4-(trifluoromethyl)phenylboronic acid was reacted as described in Intermediate X(2) with 3-iodo-4,4-dimethoxytetrahydro-2H-pyran (Intermediate X(1)) to give 3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-one (Intermediate Z(2)).

Sources & evidence

ORD record
ord-33b6c727fdd94443a44f8f339ef5cd45
Source dataset
uspto-grants-2014_04
Patent number
US08710061B2

Reaction notes

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