1-[(p-Nitrophenyl)sulfonyl]-4-(o-bromophenyl)piperazine → 1-[(p-Aminophenyl)sulfonyl]-4-(o-bromophenyl)piperazine

HRID 237028Notes

Reaction equation

HRID 237028 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Br:25])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O>[Cl-].[Cl-].[Cl-].[Ti+3]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Br:25])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 213148281-[(p-Nitrophenyl)sulfonyl]-4-(o-bromophenyl)piperazine

Product 1

HCID 213148321-[(p-Aminophenyl)sulfonyl]-4-(o-bromophenyl)piperazine

Reagents, catalysts & solvents 1

HCID 10313229titanium(III) trichlorideCatalyst

Procedure

In the manner given in Example 5B, 1-[(p-nitrophenyl)sulfonyl]-4-(o-bromophenyl)piperazine is reduced with titanium chloride (TiCl3) to give 1-[(p-aminophenyl)sulfonyl]-4-(o-bromophenyl)piperazine.

Sources & evidence

ORD record
ord-c734c2eef8e64071ab1762709b9102f7
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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