4,7-Dichloroquinoline → 1-(o-Bromophenyl)-4-[[4-[[7-chloro-4-quinolinyl]-amino]phenyl]sulfonyl]piperazine

HRID 237029Notes

Reaction equation

HRID 237029 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:23]2[CH2:28][CH2:27][N:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[Br:35])[CH2:25][CH2:24]2)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Br:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[N:26]1[CH2:25][CH2:24][N:23]([S:20]([C:17]2[CH:18]=[CH:19][C:14]([NH:13][C:2]3[C:11]4[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=4)[N:5]=[CH:4][CH:3]=3)=[CH:15][CH:16]=2)(=[O:22])=[O:21])[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 68664,7-DichloroquinolineHCID 213148321-[(p-Aminophenyl)sulfonyl]-4-(o-bromophenyl)piperazine

Product 1

HCID 213148581-(o-Bromophenyl)-4-[[4-[[7-chloro-4-quinolinyl]-amino]phenyl]sulfonyl]piperazine

Procedure

In the manner given in Example 1C, 4,7-dichloroquinoline is heated with 1-[(p-aminophenyl)-sulfonyl]-4-(o-bromophenyl)piperazine to give 1-(o-bromophenyl)-4-[[4-[[7-chloro-4-quinolinyl]-amino]phenyl]sulfonyl]piperazine.

Sources & evidence

ORD record
ord-ec2eb7881213498aa58bb5553d769691
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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