4,7-Dichloroquinoline → HCID 21314914, compound

HRID 237031Notes

Reaction equation

HRID 237031 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:23]2[CH2:28][CH2:27][N:26]([C:29]3[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:30]=3[F:36])[CH2:25][CH2:24]2)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[F:35][C:34]1[CH:33]=[CH:32][CH:31]=[C:30]([F:36])[C:29]=1[N:26]1[CH2:27][CH2:28][N:23]([S:20]([C:17]2[CH:18]=[CH:19][C:14]([NH:13][C:2]3[C:11]4[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=4)[N:5]=[CH:4][CH:3]=3)=[CH:15][CH:16]=2)(=[O:21])=[O:22])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 68664,7-DichloroquinolineHCID 21314843HCID 21314843, compound

Product 1

HCID 21314914HCID 21314914, compound

Procedure

In the manner given in Example 1C, 4,7-dichloroquinoline is heated with 1-[(p-aminophenyl)-sulfonyl]-4-(2,6-difluorophenyl)piperazine to give 1-(2,6-difluorophenyl)-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]piperazine.

Sources & evidence

ORD record
ord-aa82682a8dfd41d2b84487926376bc87
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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