Thionyl Chloride → HCID 86668135, compound

HRID 2370359Notes

Reaction equation

HRID 2370359 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:10]2[C:14]([CH3:16])([CH3:15])[C:13](=[O:17])[N:12]([C:18]3[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[C:20]([C:26]([F:29])([F:28])[F:27])[CH:19]=3)[C:11]2=[S:30])[CH:5]=[CH:6][C:7]=1[CH2:8]O.S(Cl)([Cl:33])=O>>[Cl:33][CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N:10]2[C:14]([CH3:16])([CH3:15])[C:13](=[O:17])[N:12]([C:18]3[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[C:20]([C:26]([F:29])([F:28])[F:27])[CH:19]=3)[C:11]2=[S:30])=[CH:3][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 86668138HCID 86668138, compound

Product 1

HCID 86668135HCID 86668135, compound

Conditions

Temperature
100 °C

Procedure

The title compound was prepared according to General Method 10. 4-[3-(3-Fluoro-4-hydroxymethyl-phenyl)-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-trifluoromethyl-benzonitrile (0.5 g, 1.14 mmol) was dissolved in thionyl chloride (5 mL) and the solution was stirred at 100° C. for 12 h. The reaction mixture was concentrated under reduced pressure to obtain 300 mg of product.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-987f4214d236413aa30e7f43d73293ff
Source dataset
uspto-grants-2014_04
Patent number
US08710086B2

Reaction notes

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