3-(Trifluoromethyl)phenyl isocyanate → HCID 21314889, compound

HRID 237037Notes

Reaction equation

HRID 237037 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([S:20]([N:23]4[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]4)(=[O:22])=[O:21])=[CH:16][CH:15]=3)=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.[F:31][C:32]([F:43])([F:42])[C:33]1[CH:34]=[C:35]([N:39]=[C:40]=[O:41])[CH:36]=[CH:37][CH:38]=1>C(Cl)Cl>[F:31][C:32]([F:42])([F:43])[C:33]1[CH:34]=[C:35]([NH:39][C:40]([N:26]2[CH2:25][CH2:24][N:23]([S:20]([C:17]3[CH:16]=[CH:15][C:14]([NH:13][C:7]4[C:6]5[C:11](=[CH:12][C:3]([C:2]([F:29])([F:1])[F:30])=[CH:4][CH:5]=5)[N:10]=[CH:9][CH:8]=4)=[CH:19][CH:18]=3)(=[O:22])=[O:21])[CH2:28][CH2:27]2)=[O:41])[CH:36]=[CH:37][CH:38]=1

Participants

4

Reactant 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 21314846HCID 21314846, compound

Product 1

HCID 21314889HCID 21314889, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To [[4-[(7-trifluoromethyl-4-quinolinyl)amino]-phenyl]sulfonyl]piperazine (prepared in Example 9, part D) in methylene chloride is added dropwise, at room temperature, m-trifluoromethylphenyl isocyanate in methylene chloride solution. The reaction is conducted in an atmosphere of nitrogen at room temperature for 1-5 hours. 1[[(m-Trifluoromethylphenyl)amino]carbonyl]-4-[[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]phenyl]sulfonyl]piperazine is isolated by conventional methods, e.g., filtration, chromatography.

Sources & evidence

ORD record
ord-49b1528a62114392b1fcd4f9ac946822
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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