3-(Trifluoromethyl)phenyl isocyanate → HCID 21314889, compound

Participants

Reaction Steps

To [[4-[(7-trifluoromethyl-4-quinolinyl)amino]-phenyl]sulfonyl]piperazine (prepared in Example 9, part D) in methylene chloride is added dropwise, at room temperature, m-trifluoromethylphenyl isocyanate in methylene chloride solution. The reaction is conducted in an atmosphere of nitrogen at room temperature for 1-5 hours. 1[[(m-Trifluoromethylphenyl)amino]carbonyl]-4-[[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]phenyl]sulfonyl]piperazine is isolated by conventional methods, e.g., filtration, chromatography.

Provenance & Evidence