4,7-Dichloroquinoline → HCID 21314836, compound

HRID 237039Notes

Reaction equation

HRID 237039 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:23]2[CH2:28][CH2:27][N:26]([C:29]3[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][CH3:38])=[CH:31][CH:30]=3)[CH2:25][CH2:24]2)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[CH2:36]([O:35][C:32]1[CH:31]=[CH:30][C:29]([N:26]2[CH2:27][CH2:28][N:23]([S:20]([C:17]3[CH:16]=[CH:15][C:14]([NH:13][C:2]4[C:11]5[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=5)[N:5]=[CH:4][CH:3]=4)=[CH:19][CH:18]=3)(=[O:21])=[O:22])[CH2:24][CH2:25]2)=[CH:34][CH:33]=1)[CH2:37][CH3:38]

Participants

3

Reactant 2

HCID 68664,7-DichloroquinolineHCID 21314829HCID 21314829, compound

Product 1

HCID 21314836HCID 21314836, compound

Procedure

In the manner given in Example 1C, 4,7-dichloroquinoline is heated with 1-[(p-aminophenyl)sulfonyl]-4-(p-propoxyphenyl)piperazine to give 1-(p-propoxyphenyl)-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]-sulfonyl]piperazine.

Sources & evidence

ORD record
ord-09c34ac965e54ac3bdef10848aad864a
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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