4-Nitrobenzenesulfonyl chloride → HCID 21314869, compound

HRID 237043Notes

Reaction equation

HRID 237043 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:14][C:15]([F:33])([F:32])[C:16]1[CH:17]=[C:18]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:19]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:21]=1>C(N(CC)CC)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:29]2[CH2:28][CH2:27][N:26]([C:18]3[CH:17]=[C:16]([C:15]([F:33])([F:32])[F:14])[CH:21]=[C:20]([C:22]([F:23])([F:24])[F:25])[CH:19]=3)[CH2:31][CH2:30]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 7705581-[3,5-bis(trifluoromethyl)phenyl]piperazine

Product 1

HCID 21314869HCID 21314869, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzenesulfonyl chloride, 1-[3,5-di(trifluoromethyl)phenyl]piperazine and triethylamine are stirred at reflux to give 1-[(p-nitrophenyl)sulfonyl]-4-[3,5-di(trifluoromethyl)phenyl]piperazine.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-12abcd8aa0db44c482534a4fb64bc45e
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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