4-Nitrobenzenesulfonyl chloride → HCID 21314803, compound

HRID 237052Notes

Reaction equation

HRID 237052 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:14]([O:17][C:18]1[CH:19]=[C:20]([NH:25][C:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:27])[CH:21]=[C:22]([F:24])[CH:23]=1)[CH2:15][CH3:16]>C(N(CC)CC)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:31]2[CH2:32][CH2:33][N:28]([C:26]([NH:25][C:20]3[CH:21]=[C:22]([F:24])[CH:23]=[C:18]([O:17][CH2:14][CH2:15][CH3:16])[CH:19]=3)=[O:27])[CH2:29][CH2:30]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 21314927HCID 21314927, compound

Product 1

HCID 21314803HCID 21314803, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzenesulfonyl chloride, 1-[[(3-propoxy-5-fluorophenyl)amino]carbonyl]piperazine and triethylamine are stirred at reflux to give 1-[(p-nitrophenyl)-sulfonyl]-4-[[(3-propoxy-5-fluorophenyl)amino]-carbonyl]piperazine.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-36344260d3a0449c93379874fbf8a79b
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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