4,7-Dichloroquinoline → HCID 21314870, compound

HRID 237053Notes

Reaction equation

HRID 237053 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:23]2[CH2:28][CH2:27][N:26]([C:29]([NH:31][C:32]3[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([O:39][CH2:40][CH2:41][CH3:42])[CH:33]=3)=[O:30])[CH2:25][CH2:24]2)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[CH2:40]([O:39][C:34]1[CH:33]=[C:32]([NH:31][C:29]([N:26]2[CH2:27][CH2:28][N:23]([S:20]([C:17]3[CH:16]=[CH:15][C:14]([NH:13][C:2]4[C:11]5[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=5)[N:5]=[CH:4][CH:3]=4)=[CH:19][CH:18]=3)(=[O:21])=[O:22])[CH2:24][CH2:25]2)=[O:30])[CH:37]=[C:36]([F:38])[CH:35]=1)[CH2:41][CH3:42]

Participants

3

Reactant 2

HCID 68664,7-DichloroquinolineHCID 21314854HCID 21314854, compound

Product 1

HCID 21314870HCID 21314870, compound

Procedure

In the manner given in Example 1C, 4,7-dichloroquinoline is heated with 1-[(p-aminophenyl)-sulfonyl]-4-[[(3-propoxy-5-fluorophenyl)amino]-carbonyl]piperazine to give 1-[[(3-propoxy-5-fluorophenyl)amino]carbonyl]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]piperazine.

Sources & evidence

ORD record
ord-bd5b2edf79d6479d8277d9e1bf811089
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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